The advanced version of CHRONECT Symbiosis enables powerful UHPLC up to 1000 bar.
This
system offers all the advantages of online SPE and simultaneous SPE
sample preparation and LC-MS analysis. Additionally, the Online-SPE
system is fully compatible with UHPLC columns up to 1000 bar using
disposable PEEK-SPE cartridges with 10 x 1 mm ID. Due to the reduced SPE
cartridge volumes (8 µL, 10 x 1 mm ID) this system is compatible with
the lower UHPLC flow rates without losing UHPLC resolution.
Multi-component UHPLC-MS analysis including fully automated sample
preparation within 2-4 minutes can be achieved.
The system offers
all the advantages of online SPE to increase assay performance while
reducing method development time and manual sample preparation steps.
With the Solvent Selector in the SPH1299 pumps and the optional Column
Selector in the new Mistral™ you can also run multiple batches under
different LC conditions. You can even choose to perform direct injection
or extraction without reconfiguring your system hardware. The mixing
and dilution routine is handled by the innovative and flexible CHRONECT
Robotic Autosampler. Sample preparation steps like the addition of
internal standard can also be performed.
While the cleaning is
performed on the left cassette, the SPE-UHPLC-MS can run simultaneously
on the right cassette. Forward and backward washing is possible,
providing clean samples and high assay sensitivity when performing your
multi-component UHPLC analysis. Peak focusing can be realized with mixed
SPE cartridges and an additional SPH1299 UHPLC gradient pump.
CHRONECT
Symbiosis is controlled by CHRONOS Symbiosis. CHRONOS controls the
entire system in an efficient and intelligent way and increases the
sample throughput by overlapping processes. The cartridge is prepared
while the analysis is running. CHRONOS organizes the connection to the
LC-MS. All CHRONECT Symbiosis systems process multiple batches quickly
and reliably with highest analytical performance, completely unattended.