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Sepax C-Pro Cell Processing Instrument

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Code: #21905

Supplier: Cytiva

Use this flexible instrument in combination with protocol software and kits to automate and functionally close specific operations in cell therapy.


  • The Sepax C-Pro Cell Processing System, which is comprised of the instrument, Sepax C-Pro protocol software, and kits, allows you to combine multiple processing steps in a versatile manner. These steps include but are not limited to enrichment, magnetic bead incubation, spinoculation, concentration, washing, dilution, and splitting.

    • Support your requirements and system implementation. Automated and functionally closed system to support GMP compliance.
    • Simplify your operations. Compact design and user-friendly interface minimize your space and resource requirements.
    • Maintain flexibility. Sepax C-Pro is a multipurpose solution allowing you to perform diverse and dedicated applications.
    • Simplify record-keeping. Sepax C-Pro can transmit instrument data and alarms for remote monitoring or for incorporation into a Chronicle eSOP.
    • Keep operations running smoothly. Integrate with Chronicle manufacturing automation software to monitor all connected instruments (Sepax C Pro and others) and manage service records.

    Cell therapy applications. The Sepax C-Pro Cell Processing Instrument has been used to prepare CAR T cells, natural killer cells (NK cells), and other cell types. Sepax C-Pro can be part of a robust CAR T cell manufacturing workflow that is adaptable for cGMP compliance in production of clinically relevant doses. In a natural killer cell manufacturing workflow the Sepax C-Pro system was used with BeadWash C-Pro protocol software to functionally close and automate incubation with magnetic beads for CD3 depletion and CD56 selection. These steps were included in a workflow with xeno-free expansion that generated 1 × 109 primary human NK cells and can be adapted for GMP compliance.

    Instrument flexibility. In combination with the appropriate protocol software and single-use kit, the instrument can perform the following operations:

    • Concentrate cells from fresh apheresis product via plasma depletion
    • Concentrate cells and remove platelets from fresh apheresis units
    • Incubate magnetic beads onto the cell fractions obtained from apheresis units – sequence concentration, platelet depletion, bead incubation, and washing
    • Enrich mononuclear cells fraction via a density gradient medium
    • Concentrate, wash, and transduce isolated cells by spinoculation
    • Dilute, concentrate, and wash fresh or frozen cellular product
    • Dilute and split cellular products into multiple bags for accurate dosing

  • ParameterSepax C-Pro Cell Processing Instrument
    ConnectivityFour USB slots and two ethernet ports 
    Core TechnologyElectric centrifugation motor and pneumatic circuitry for piston drive
    Pressure monitoring sensor
    Optical line sensor 
    DimensionsW: 27 cm, L: 40 cm, H: 46 cm (10.6” × 14.7” × 18.1”) 
    Operating conditionsTemperature range 0°C to 50°C
    Humidity range 20% to 75%, non-condensing
    Altitude 2000 m, 80 kPa 
    Power1000 W, 100-240 VAC, 50/60 Hz 
    SoftwareCompatible with Sepax C-Pro protocol software only Windows® XP embedded and proprietary GMAP application software 
    Storage and transport conditionsTemperature range 7°C to 27°C
    Humidity range 30% to 75%, non-condensing  
    TraceabilityBarcode reader
    Data management with PDF reports and procedural graphs – data saving capacity on the instrument 32 log files, 50 PAT files, and 50 report files (PDF) 
    Unified digital platformChronicle automation software connects our cell therapy instruments and third-party instruments 
    User interfaceColor touchscreen with an intuitive graphical user interface (GUI) 
    Weight16.3 kg (35.9 lb) 
    Pack size