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PT-DR Dispersion Releaser

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Code: #22308

Supplier: Pharma Test Apparatebau AG

The Dispersion Releaser PT-DR is a dialysis-based apparatus for the release testing of nanomedicines, microformulations and semi-solid dosage forms within a standard dissolution tester. It is composed of a sample holder cell serving as the donor compartment for dispersed dosage forms. A dialysis membrane is disposed around this housing. This donor chamber is agitated by a paddle stirrer that is connected to the USP Apparatus 2.

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  • The Dispersion Releaser is connected to the dissolution tester by a special coupling directly affiliated to the stirrer shaft. This way the Dispersion Releaser can be hooked to the coupling and as well easily removed from the stirrer shaft for preparation and cleaning purposes. This ensures a direct transfer of the stirring movements to the stirrer of the Dispersion Releaser.
     
    Basically the Dispersion Releaser consists of a donor and acceptor compartment. The donor compartment is a cylindrically construction which contains the substance to be tested. This construction is surrounded by a membrane, fixed through two O-rings, which acts as barrier between donor and acceptor compartment.
     
    In the inside of the donor compartment is a small paddle, with integrated magnets, directly influenced and controlled by the stirrer shaft of the dissolution tester. Through the integrated magnets an external magnetic stirrer, located at the bottom of the donor, is driven to mix the media in the acceptor compartment.

  • Providing a uniform, constant and reliable release of the active substance which leads to reproducible results
    Tube membranes with a width between 26-32 mm can be used
    Typical materials for membran are cellulose ester and regenerated cellulose

  • Reproducible release through the additional stirring movement in the donor compartment
    Increased throughput of the dialysis process
    Mixing inside the donor and the acceptor compartment for an optimal homogeneous suspension

 
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